How long does Nimesil last for fever and toothache?

Release form, composition

The drug Nimesil is available in a dosage form, a powder for the preparation of a suspension, which is intended for oral administration. It has a light green color, coarse grain, and an orange scent. The main active component of the drug is nimesulide, its content in 1 sachet of powder is 100 mg. The drug also contains additional compounds, which include:

• Sucrose.
• Orange flavor.
• Ketomacrogol.
• Anhydrous citric acid.
• Maltodextrin.

Nimesil powder is packaged in aluminum foil bags of 2 g each. A cardboard pack contains 9, 15 or 30 bags.

pharmachologic effect

The main active ingredient of Nimesil is nimesulide, which is a sulfonamide. This substance suppresses the activity of cyclooxygenase-2 in the body, the enzyme responsible for the production of prostaglandins, which are synthesized during the development of pathological processes. A decrease in the amount of synthesized prostaglandins, as a result of exposure to nimeslin, helps to reduce irritation of nerve endings in the area of ​​inflammation, which, in turn, leads to the disappearance of pain.

After entering the body, the drug begins to act actively. It is easily absorbed from the stomach and intestines, penetrates the blood, binding to plasma proteins. The largest amount of active substance in the blood is observed approximately 2-3 hours after taking the medicine. The main metabolic processes take place in the liver, and the resulting inactive products are eliminated within 6 hours (half-life).

According to research results, repeated use of the drug does not cause accumulation.

Who needs Nimesil?

The medicine can be bought without a doctor’s prescription, but this does not mean that such a remedy should become a panacea for hundreds of ailments. Pain is just the tip of the iceberg; you should always look for the cause that triggered the manifestation of this symptom. Therefore, for temporary pain relief, you can take Nimesil. As for the use of pharmaceuticals for medicinal purposes, this should always be agreed upon with a specialized doctor.

List of indications:

• injuries;
• pain during menstrual bleeding;
• toothache;
• ailments of the musculoskeletal system and joint tissue;
• inflammatory processes in the body;
• dislocations, etc.

This medication has proven itself well in the pharmacological market. This is explained by its ease of use and high efficiency. Active components help to pacify pain even of unknown etiology. But in this case, symptomatic treatment alone is not enough. You should definitely visit a doctor and undergo a comprehensive examination.

“Nimesil” deserves special attention in the treatment of pathologies of the musculoskeletal system, as well as joints. The substances included in the medicine help strengthen joints and also suppress the inflammatory process.

Few people think about the principle of action of medicines, because the end result is important. Once in the body, Nimesil begins to actively act on the centers that provoke pain. Their activity is suppressed, as a result of which the pain weakens or completely subsides.

Important! Children under twelve years of age are strictly contraindicated from taking this medication.

Indications for use of Nimesil

Nimesil is prescribed for:

• pain syndromes of various origins (headache, dental pain, menstrual pain, consequences of injuries, postoperative pain, pain from rheumatism, etc.);
• infectious and inflammatory diseases (traumatic and postoperative inflammation)
• degerative and inflammatory diseases of the musculoskeletal system (arthritis, osteoarthrosis, osteochondrosis, bursitis, radiculitis, rheumatism, etc.);
• urological, gynecological and vascular diseases;
• diseases accompanied by increased body temperature.

This remedy is appropriate both for long-term treatment therapy and for dulling severe pain syndromes.

Nimesil for children

Nimesil (as well as tablets or ointment based on nimesulide ) is prohibited for use in children under 12 years of age. The instructions for the drug for children indicate that the method of using Nimesil (how to apply and how to dilute the powder) is no different for other age groups. How to use the powder, how to dilute Nimesil in powder, as well as how to drink Nimesil in powder, is described in the section “Instructions for use of Nimesil (Method and dosage)”

Is it possible to give Nimesil to children with fever?

This medicine is not the drug of choice for reducing body temperature, although it has a mild antipyretic effect. Nimesil should be used only for the purpose of relieving mild and moderately mild pain. Prohibited for the treatment of children under 12 years of age.

Contraindications

Before taking the medication, you must eat the contraindications indicated by the manufacturer. In particular, it is prohibited to take it in the following situations:

• Hypersensitivity to the active base (nimesulide) or an auxiliary component of the drug.
• History of hyperergic reactions of the body: rhinitis, urticaria, bronchospasm, laryngospasm associated with taking any drug from the NSAID group, including nimesulide.
• History of hepatotoxic reactions of the body to nimesulide.
• Simultaneous treatment with other drugs that have hepatotoxic effects (especially from the NSAID group).
• Inflammatory processes in the intestines in the acute phase (Crohn's syndrome, nonspecific ulcerative colitis).
• Recovery period after coronary artery bypass surgery.
• Fever that accompanies colds and acute respiratory viral infections.
• A combination of bronchial asthma, polyposis of the paranasal sinuses or nose with a recurrent course and a history of intolerance to NSAIDs;
• Exacerbation of a stomach or duodenal ulcer;
• History of ulcer with bleeding or perforation;
• History of cerebrovascular and other bleeding;
• Diseases accompanied by bleeding;
• Severe bleeding disorder;
• Severe heart failure;
• Severe renal failure;
• Confirmed hyperkalemia;
• Liver disease in the acute phase;
• Liver failure;
• Children under 12 years old;
• Pregnancy, lactation;
• Drug addiction, alcoholism.

Prescribed with caution for the following pathologies and factors:

• heart failure of any degree;
• severe arterial hypertension;
• diabetes mellitus type 2;
• IHD;
• hereditary fructose intolerance;
• malabsorption of glucose-galactose;
• sucrose-isomaltose deficiency;
• dys- or hyperlipidemia;
• cerebrovascular pathologies;
• severe somatic illnesses;
• arterial diseases (peripheral);
• infection caused by Helicobacter pylori;
• creatinine clearance less than 60 ml/min;
• long-term treatment with NSAIDs;
• elderly age;
• smoking.

Side effects

Before using the medication, it is extremely important to familiarize yourself with the list of possible side effects provided by the manufacturer:

• increased potassium levels in the blood;
• mild general weakness, decreased body temperature;
• anemia, thrombocytopenia;
• problems with urination, development of kidney failure;
• sweating, skin rashes of various types, dermatitis, erythema, nephrotic edema;
• disturbances in the normal functioning of the liver (in particular, the synthesis of certain enzymes);
• headache and dizziness, causeless anxiety, apathy, drowsiness;
• visual impairment;
• shortness of breath, coughing attacks;
• disruption of the gastrointestinal tract, bleeding, ulcers;
• increase in pressure.

In order to reduce the likelihood of side effects, it would be best to minimize the dose of medication taken and shorten the duration of treatment with it as much as possible.

Overdose

The use of Nimesil in large quantities can lead to an overdose , the symptoms of which are indicated in the instructions as follows:

• apathy;
• drowsiness;
• the appearance of vomiting;
• increased blood pressure;
• labored breathing;
• nausea;
• stomach ache;
• exacerbation of kidney diseases;
• sometimes stomach bleeding occurs;
• anaphylactic shock;
• coma.

With a small therapeutic dose, such symptoms are reversible, and in other cases symptomatic treatment is prescribed. In case of overdose, induce vomiting to empty the stomach and then take a laxative or activated charcoal. It is recommended to keep the activity of the liver and kidneys under control.

How to dilute Nimesil powder - instructions for use

According to the instructions, Nimesil powder is intended for preparing a suspension that is taken orally.

One sachet is dissolved in 1 glass of water with a volume of 100 ml. The prepared suspension should be used immediately; it cannot be stored. The average therapeutic dosage is 100 mg of nimesulide (1 sachet) 2 times a day.

The maximum duration of treatment with Nimesil powder should not exceed 15 days. Dosage adjustment is usually not required for adolescents over 12 years of age, the elderly, and patients with concomitant mild renal impairment.

Drug interactions

The drug enhances the effect of medications that are used to reduce blood clotting. Nimesil can also increase the effect of furosemide. When taking Nimesil and methotrexate simultaneously, side effects may worsen. Nimesulide quickly binds to plasma proteins, so persons treated with sulfonamides and hydantoin should be under close medical supervision. The drug enhances the effect of cyclosporine on the kidneys. If Nimesil is used simultaneously with lithium preparations, the concentration of lithium in the plasma will increase.

Treatment with Nimesil requires caution if blood pressure medications, diuretics, or other anti-inflammatory and painkillers are used in combination with it.

Interaction

When used simultaneously with glucocorticosteroids, the risk of ulcers or bleeding from the stomach and intestines increases.

When used with antiplatelet agents and selective serotonin reuptake inhibitors, the likelihood of gastric or intestinal bleeding also increases.

Anti-inflammatory nonsteroidal drugs may enhance the effects of anticoagulants, so this combination is not recommended for persons with severe coagulation disorders. If this combination cannot be avoided, careful monitoring of blood clotting parameters is necessary.

Anti-inflammatory non-steroidal drugs can weaken the effects of diuretics.

Nimesulide is able to temporarily reduce the evacuation of sodium and potassium under the influence of Furosemide and thereby weaken the diuretic effect of the latter. It must also be remembered that such co-prescription of drugs requires caution in persons with impaired renal and cardiac function.

Anti-inflammatory non-steroidal drugs may weaken the effect of antihypertensive drugs. In persons with compensated renal failure, with the simultaneous administration of ACE blockers, angiotensin receptor antagonists of the second type or agents that suppress cycloxygenase, progression of deterioration of renal function and the development of reversible acute renal failure .

Anti-inflammatory non-steroidal drugs reduce the clearance of lithium, which causes an increase in the level of the latter in the blood.

When prescribing Nimesil less than a day before or after using Methotrexate, caution must be exercised, since in such cases the content of methotrexate in the blood and its toxic effects may increase.

Nimesulide can stimulate the nephrotoxicity of cyclosporines.

special instructions

According to Nimesil's instructions, if the patient has a risk of ulcers, gastrointestinal bleeding, as well as with simultaneous treatment with drugs from the above, Nimesil therapy is started with the lowest dose, monitoring the patient's condition. At the slightest side or undesirable reactions, treatment is stopped.

1. Nimesil contains sucrose, which should be taken into account by patients with diabetes: 1 sachet contains 0.15-0.18 XE.
2. If ARVI and colds occur during Nimesil therapy, treatment is stopped.
3. During treatment with Nimesil, caution should be exercised when driving a car and performing precise, dangerous work.

Analogs

The following drugs are similar in composition to the active substance nimesulide: Nemulex, Actasulide, Aponil, Ameolin, Aulin, Nimesulide, Nimulid, Sulaydin, etc. Some of them have a much lower cost with the same effectiveness as Nimesil.

The difference between granules for preparing a suspension and tablets (cheaper) is only that the effect occurs a little faster, due to faster absorption of the suspension, but the effectiveness remains the same.

Nimesil price, where to buy

The price of Nimesil powder (9 sachets) in Russia is about 300 rubles. For comparison, the price of 1 sachet of Nimesil is 30-40 rubles.

The average price in Ukraine for drug No. 1 is approximately 10 hryvnia, and the price of a package containing 30 sachets fluctuates around 300 hryvnia.

How much does the analogue of Nimesil Nise cost?

The cost of this drug in Russia in the form of 100 mg tablet No. 20 is about 200 rubles, and the ointment of the same name 1% 20 grams will cost 200-250 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Nimesil granules for Prig Susp.
  for internal approx. 100 mg 30 pcs. Laboratorios Menarini/Fine Foods & Pharmaceuticals RUB 795 order
• Nimesil granules for Prig Susp. for internal approx. 100 mg pack. 2g 9 pcs Laboratorios Menarini/Fine Foods & Pharmaceuticals

  RUB 374 order

Pharmacy Dialogue

• Nimesil (pack 2g No. 9)Berlin-Chemie AG/Menarini/FineFoods

  RUB 401 order

• Nimesil (pack 2g No. 9)Berlin-Chemie AG/Menarini

  430 rub. order

• Nimesil (pack 2g No. 30)Berlin-Chemie AG/Menarini

  RUR 749 order

• Nimesil (pack No. 1)Berlin-Chemie AG/Menarini

  38 rub. order

show more

Pharmacy24

• Nimesil 2 g N30 powder Laboratorios Menarini S.A./Fine Foods and Pharmaceuticals N.T.M.S.P.A., Spain/Italy
  279 UAH.order

PaniPharmacy

• Nimesil Nimesil granules for the preparation of suspension 100 mg 2 g No. 30 Spain, Lab. Menarini

  314 UAH. order

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Reviews from doctors and people

1. Svetlana Kharkovaya, dentist. Toothache can be quite severe and should not be tolerated. Taking Nimesil can help the patient. Of course, it is very important to pay attention to possible side effects and contraindications - not everyone can take the medicine. In some cases, I recommend Nimesil to relieve pain after treatment or tooth extraction. And I can say with confidence that during my long practice, no one complained that Nimesil did not help or that it made me feel ill.
2. Ekaterina Menshikova. Nimesil became a real salvation for me at the time when I was treating my teeth. The pain was unbearable, both before visiting the doctor and in the first days after treatment (two teeth had to be removed due to inflammation). The advantage of this medicine is that it is easily diluted and begins to act very quickly. Of course, there are cheaper analogues - but I don’t want to experiment, since Nimesil has already been tested by time.

Painkillers Powder Nimesil Laboratories Menarini S.A. - review

This will probably be my shortest review????

I decided to get rid of my wisdom teeth. They started to shift all the teeth (10 years ago, but I, like a true Estonian, pulled as hard as I could????).

A week after removal

I read dozens of reviews about how THIS happens. Complete horrors and fears. Most reported terrible pain for at least a week after tooth extraction.

In the morning at the appointment, the surgeon “reassured”: “Come back after lunch, you have a difficult case, there’s work for two or three hours.”

I wrote out a prescription for antibiotics. At the pharmacy I immediately bought antibiotics, prebiotics, and painkillers. Well, I definitely did. The doctor said it was impossible because I was breastfeeding, but I’m impressionable, so I decided to play it safe and buy strong painkillers.

Assortment of medications after tooth extraction. There is also not enough cream for skin irritation under a child’s diaper caused by one of the drugs

I bought three expensive and three cheap Nimesil.

I took it individually. Imported, from Berlin Hemi, they only give 3 pieces. I don’t know how much is in the box, I initially only wanted 3 bags.

Nimesil after wisdom tooth removal

Nimesil for toothache

• And this is the Russian nimesil:

Cheap nimesil

They don't give instructions; they remain in the box at the pharmacy. I read the instructions on the Internet.

Price 27 rubles for 1 sachet.

Price for nimesil

All in all.

They pulled out one of my wisdom teeth at 3 pm. They stitched up the wound and released him in peace???? the surgeon warned that the anesthesia would last for 4 hours.

6 hours passed and there was still no pain. The tongue, lips, everything remained “frozen”.

I put the children to bed.

And so, just enchantingly quickly, instantly, in a couple of minutes, the anesthesia wore off. I started to become afraid of the pain.

Really shivered and shook, precisely from the pain.

She quickly stirred the contents of the bag and drank.

Damn. How painful. I frantically began to search for information about when it would begin to let go.

Me - about 7 minutes later. The pain began to dull slightly. The chills stopped.

After 20 minutes the pain was rated 2 out of 10.

???????????? In general, with acute pain after wisdom tooth removal, Nimesil helped me within 20 minutes . I fell asleep peacefully. In the morning the pain was not so severe, it was saved by keterol and ibuprofen, they are allowed during breastfeeding.

By the way, about this. I showed selfishness by drinking this drug. On the eve of the removal, I spoke with a guardianship consultant, who strictly did not recommend Nimesil. But I thought that enduring such pain was unbearable. But Nurofen and similar drugs are much weaker.

The price of my selfishness is irritation on the child’s bottom. Maybe from anesthesia, maybe from a.b., maybe in combination. But it was nimesil that the consultant asked not to use.

Conclusion: it relieves pain quickly and powerfully, but when breastfeeding it is better to do without it!