The problem of acute toothache or pain in the gums is faced not only by people who neglect oral hygiene and visits to the dentist. Even with proper care of teeth and gums, a person may experience pain associated with inflammation of the gums (flux) due to hypothermia, or pulpitis.
For such cases, there are a number of drugs that fight pain and inflammation. One of the most effective medications is the drug Nise for toothache based on nimesulide, which is recommended by most dentists as an anesthetic.
Nise is a non-steroidal anti-inflammatory drug.
Does Nise help with toothache?
Nise helps with toothache. Pharmacological properties and patient reviews give grounds to declare the effectiveness of the drug in dentistry, which is taken for the purpose of pain relief. Pain is often caused by an inflammatory process that develops in the pulp and periodontium.
The active ingredient Naiza has the ability to block the attack and development of the inflammation process. Therefore, the remedy is recommended for the manifestation of painful sensations of a different nature, in particular in the tooth.
Pharmacological properties
Nise is an analgesic drug. This drug belongs to the group of non-steroidal anti-inflammatory drugs that take part in the synthesis of prostaglandins. Nise has anti-inflammatory, analgesic and antipyretic effects.
When taking the Nise tablet, toothache is dulled.
The active substance of Nise, nimesulide, has an inhibitory effect on prostaglandins. Prostaglandins are components that cause an inflammatory process that provokes pain. The active substance inhibits their production process, thereby reducing the intensity of pain.
The drug Nise is effective for severe and mild toothache. However, it can slightly weaken and dull strong painful sensations, but it will not be able to eliminate them completely.
When taken orally, this drug is rapidly absorbed from the gastrointestinal tract. After administration, the effect begins within 20-30 minutes. The maximum effect is achieved after 2-3 hours. The period of action is from 6 to 12 hours.
The main biotransformation occurs in the liver. The bioavailability level is 90%. It is excreted primarily by the kidneys along with urine. Excreted in the form of metabolites. The half-life is 3 hours.
Composition and principle of action
Nise in tablet form
The main active component of the drug, which directly blocks pain, is nimesulide. In addition to it, the composition includes auxiliary substances:
- sorbitol;
- aspartame;
- silicon dioxide;
- microcrystalline cellulose;
- talc;
- fruit flavoring, etc.
Nise is available in different forms. For toothache, it is recommended to take tablets and suspensions. For pain relief and relief of inflammation in joints, ligaments and muscles, the drug in the form of an ointment or gel is suitable.
The principle of operation is based on the penetration of active substances into the blood, after which the synthesis of prostaglandins is suppressed at the site of inflammation. Nimesulide, in combination with excipients, selectively inhibits cyclooxygenases, which actually dulls pain. At the same time, the drug does not change hemostasis, that is, the blood retains both its liquid state and its previous chemical composition.
Nise has anti-inflammatory, antipyretic and analgesic effects. The main metabolic product (active hydroxynimesulide) does not accumulate in the body with long-term use and is excreted naturally through the kidneys.
In what forms is it produced and its constituent components?
The analgesic drug Nise can be produced in different forms. Therefore it can be used in different ways.
In pharmacies Nise is found in the following forms:
- In the form of dispersible tablets with a dosage of the active ingredient of 50 mg and in the form of regular tablets with a dosage of 100 mg. The tablets are placed in cell blisters of 10 pieces. Blisters are packed in a cardboard box
- In the form of a suspension for oral use. 5 ml of suspension contains 50 mg of the active ingredient. The suspension is placed in dark 60 ml bottles. The bottles are packed in a cardboard box, with an additional dosage cap included.
- In the form of a 1% gel for external use. 1 gram of gel contains 10 mg of the active component. Available in aluminum tubes with a volume of 20 grams. The tube is placed in a cardboard package
Components:
- Active substance – Nimesulide
- Additional items:
- Calcium hydrogen phosphate
- Microcrystalline cellulose
- Corn starch
- Sodium carboxymethyl starch
- Magnesium stearate
- Silicon dioxide colloidal
- Talc
Instructions for use
Nise in suspension form
Before taking the drug, you must read the instructions. This will prevent side effects from increasing the dosage or not following health restrictions.
Teenagers over 12 years of age and adults can use Nise in tablets . The daily dose involves taking the drug 2-3 times (after meals), 1 piece each, washed down with clean water (150-200 ml).
For severe pain, the dosage is increased to 4 tablets, but it should not exceed 200 mg for adults and 100-150 mg for children. It is recommended to maintain equal intervals between the use of pain medication (at least 3-4 hours).
The dispersible form of the drug is absorbed better by the body, so the effect occurs in a shorter period of time. This product is dissolved in the amount of 1 teaspoon per glass of water.
A more convenient form of release for children under 12 years of age is Nise in suspension . For 1 kg of a child’s weight, 5 mg of medication is needed. The dose obtained by multiplication is divided into 2-4 doses during the day.
The drug, regardless of the form of release, should be taken for no more than 10 days. During this time, you need to set aside time to visit the dentist in order to determine the diagnosis and begin treatment.
How to use for toothache in children
Nise tablets can be given from 12 years of age.
It is recommended that children take Nise tablets when they reach 12 years of age. You can also focus on the child’s body weight; the figure should exceed 40 kg. The suspension is intended for children starting from 2 years of age.
The dosage for use is calculated based on the baby’s weight (5 ml of product per 1 kg). The resulting figure is divided into several steps, which are carried out throughout the day.
You should make an appointment with a doctor as soon as possible; Nise does not have a therapeutic effect on the progression of dental diseases.
Contraindications
There are some restrictions regarding taking the drug that you should pay attention to when purchasing. The drug is contraindicated in cases where there are such health problems:
- disruptions in the functioning of the digestive system;
- stomach ulcer;
- intestinal infections;
- hepatitis (any type);
- internal bleeding and poor blood clotting;
- frequent problems with blood pressure;
- kidney and liver problems;
- cardiovascular diseases, attacks of bronchial asthma;
- polyps;
- frequent manifestation of dermatoses;
- eye diseases.
Age restrictions have also been established; the drug is recommended for children from 2 years of age. Pregnant and breastfeeding women should avoid using Nise, as should those who have an allergic reaction to the components of the product (especially aspirin).
It is important to note the property of drugs in this group to dull the reaction, which is due to the hypnotic effect. Therefore, people who spend most of their time driving or doing work that involves risking their lives are not recommended to take Nise.
Patients diagnosed with diabetes mellitus should first consult with their doctor about the possibility of using the drug.
Side effects
Ignoring contraindications or using Nise in combination with other medications, as well as alcohol, can cause side effects that manifest themselves as:
- dizziness, migraine attacks;
- nausea, vomiting;
- severe heartburn;
- formation of an allergic rash on the skin;
- diarrhea;
- physical weakness, drowsiness;
- signs of toxic hepatitis.
In this case, blood test parameters can change dramatically, reflecting a low level of leukocytes, anemia, thrombocytopenia, etc. In the case of a severe allergic reaction, anaphylactic shock is possible.
Drug interactions
Nise can increase the toxicity and activity of certain medications. This occurs due to the struggle of active substances for binding to plasma proteins. The drug interacts with Cyclosporine, Phenytoin, Methotrexate, Digoxin. Nise affects the effectiveness of the following groups of drugs: NSAIDs, diuretics, drugs with lithium, antihypertensives, oral hypoglycemics, anticoagulants.
Advantages and disadvantages
Nise will help temporarily relieve toothache.
Toothache, as we know, is very difficult to endure, so the purpose of using the drug is to reduce the pain or completely eliminate it. Nise helps achieve this effect. Already 20-30 minutes after using the product, significant relief occurs. The body's reaction time to the dose taken depends on the individual characteristics of the person.
The main advantages of the pain reliever:
- rapid blocking of pain syndrome;
- can be purchased at any pharmacy at an affordable price;
- no doctor's prescription required;
- the drug is combined with other drugs of different groups (anti-inflammatory, antihistamines, antibiotics, etc.).
Disadvantages of Nise:
- eliminates pain only temporarily, the dental problem is not solved, so a trip to the doctor is inevitable;
- Before use, you should carefully read the contraindications; the drug has some restrictions, non-compliance with which causes serious health complications.
Indications
In addition to toothache, the indications are as follows:
- rheumatoid, psoriatic arthritis;
- inflammation of ligaments and tendons, dislocations and sprains of the capsular-ligamentous apparatus;
- bursitis (inflammation of the joint capsules), including pro-traumatic inflammation of soft tissues;
- joint pain during exacerbation of gout;
- myalgia;
- osteoarthritis;
- pain syndrome of various origins, including lumbago with sciatica, algodismenorrhea (recurrent female pain), headache, pain syndrome after surgery, etc.
Learn how to treat tooth sensitivity. Why are nylon prosthetics banned in Europe? The answer is here.
Analogues for toothache and prices
Not every pain reliever is effective for toothache. The table shows examples of drugs that are recommended for use in the absence of Nise.
| Toothache medications _ _ | |
| Drug name | Price, rubles |
| Ketanov (10 mg, 20 tablets) | 69 |
| Ketorol (10 mg, 20 tablets) | 50 |
| Nurofen (capsules 200 mg, 16 pcs.) | 261 |
| Nimesil (100 mg, 30 sachets) | 674 |
| Nimesulide (tablets 100 mg, 20 pcs.) | 188 |
| Tempalgin (20 tablets) | 123 |
| Spasmalgon (20 tablets) | 149 |
| Pentalgin (24 tablets) | 168 |
Ketanov Ketorol Nurofen Nimesil Nimesulide Tempalgin Spazmalgon Pentalgin
Popular questions
To make information about the drug Nise more complete and reliable, it is recommended that you familiarize yourself with popular questions. Having received answers to them, you will be able to use the pharmacological drug correctly, without harming your health and the lives of loved ones.
- How long does Nise last for toothache?
When entering the body, the substances included in the composition are quickly absorbed into the blood, as a result of which the pain sensations are weakened or disappear altogether. The effectiveness of the drug is high, its effect is observed even during acute attacks of toothache. However, Nise has no effect on the progression of the disease, and temporary relief is limited to four hours. Efficiency increases if the degree of painful manifestations is mild or moderate.
- How long does it take to work? How fast?
The action of the active components of the drug, aimed at dulling pain, begins 20 minutes after administration. The duration can increase to 30 minutes, which is due to the reaction and characteristics of the body in each individual case.
- How much can you drink per day?
For toothache, adults are recommended to take Nise 1 tablet up to 3 times a day with an interval of at least 3-4 hours. Reducing the time between use of the drug and increasing the dosage is allowed only in acute forms of pain. However, the total daily number of tablets should not exceed 4 pieces, which corresponds to a dosage of 200 mg. Children should not increase the dose above 150 mg.
Nise is available not only in tablets, but also in the form of ointment and gel. They have one main active ingredient – nimesulide. However, this is not a basis for using ointment/gel to solve dental problems, since this form is intended for external use.
The drug Nise copes with pain quite effectively, so if repeated taking of the pill does not give the desired result, it is better to see a doctor as soon as possible. It’s not worth wasting time testing other painkillers; the situation can only get worse.
How to treat tooth pain
If you have acute pain in your teeth, you should not take painkillers regularly. In this case, the best solution would be to immediately contact your dentist. If you experience severe pain, you do not need to make an appointment and wait several days for your turn. Acute pain is a reason to admit the patient immediately and without an appointment at the nearest district clinic. Some medical institutions provide such assistance around the clock.
Principles of treating toothache
- Painkillers are not a means of dental treatment. Nise, although claimed to be an anti-inflammatory agent, is not a panacea for dental diseases. It only relieves pain without affecting the cause of its occurrence. Most dental inflammations can only be cured in a dental office. Often, pain relief with painkillers leads to the disease developing and requiring tooth extraction. If you have any unpleasant symptoms in the gums or teeth, you need to promptly go to the dentist. Tablets are indicated only to relieve symptoms for the period necessary to visit a doctor.
- Most painkillers, including Nise, have many contraindications and side effects. Patients cannot distinguish powerful drugs from weak ones, so they think that they all work the same way. Nise is a strong drug that can cause real complications if used incorrectly or if instructions are ignored. The drug must be prescribed by a doctor who will take into account all the individual characteristics of the patient’s condition.
- If there is no improvement after taking 1-2 tablets of Nise, you should not shorten the interval between doses and try to enhance the effect. Often one tablet is enough to relieve pain. If it does not help, then the problem lies not in the drug, but in the nature of the disease. An overdose of Nise will harm the liver and kidneys without having any therapeutic effect.
Visit the dentist
If you have an acute toothache, the cause cannot always be cured at the first appointment, so the first stage can be carried out at the clinic, and then enroll in a private clinic to receive more comfortable treatment. First of all, the dentist can only open the festering areas, install drainage, assess the patient’s condition and give recommendations that will help relieve the symptoms.
Acute pain in a tooth is an indication for urgent dental care also because it indicates a critical disorder in the tooth, which can lead to its loss and complications in other areas. You can postpone treatment only if it is not possible to visit a doctor right away.
Patients often take painkillers when teething wisdom teeth. The misconception that such pain cannot be treated in a dental office can lead to serious consequences. When a wisdom tooth erupts, the gums become swollen and inflamed. It literally exfoliates under the influence of the tooth, which causes extremely unpleasant long-lasting sensations. It is important to remember that complicated wisdom tooth eruption can even lead to death (pericoronitis).
Nise's popularity is due to many factors: it is affordable, effective and prompt. But most patients don't pay attention to the long list of side effects, because they are used to the fact that most often they are the company's insurance against unwanted lawsuits. In the case of Nise, these warnings are real, so only an experienced doctor can prescribe the drug.
Sources used:
- Therapeutic dentistry. Anesthesia. Bleaching. Filling. Endodontics / Edited by E.V. Borovsky. - M.: Dentistry, 2005.
- Local anesthesia in dentistry. Tutorial. - Moscow
- American Academy of Family Physicians (USA)
