Ketanov 10 mg 100 pcs. film-coated tablets

Pharmacological properties

Ketanov is an anti-inflammatory non-steroidal drug with systemic effects. This drug has powerful analgesic properties.

Ketanov is one of the best remedies for reducing toothache.
When using this medicine, there is a triple effect on the lesion:

• Antipyretic effect
• Anti-inflammatory effect
• Painkiller effect

The effect of the drug Ketanov is not aimed at suppressing the cardiovascular system and respiratory centers. The use of this drug does not affect the psycho-emotional state of the patient.

The active component, ketorolac, once it enters the body, immediately begins to carry out all its direct functions. Due to its presence in the mucous membranes and muscle tissue, prostaglandins are not produced, which cause inflammation and pain.

After the patient takes the first tablet, the process of relieving not only toothaches occurs in his body, but also painful feelings in other localizations disappear.

After taking Ketanol, the pain goes away quite quickly and for a relatively long time

Usually, after taking it, it is enough to wait 30-40 minutes for all the painful sensations to go away and a feeling of relief to set in. The period of action of the drug is from 4 to 8 hours.

The duration of action depends on the form of release of the medicine, on the intensity of pain and on the individual characteristics of the patient’s body.

Excretion occurs through the genitourinary system along with urine. For this reason, it is not recommended for people with kidney disease. Excretion occurs in the form of metabolites.

In what form is it produced?

The drug Ketanov is available in several forms:

• In tablet form. The tablets have a round, biconvex shape. The tablets have a white structure and are engraved with “KTV” on one side. The tablets are placed in blisters of 10 pieces. One cardboard package may contain 1, 2, 3 and 10 blisters
• In the form of injections for intramuscular administration. The solution has a transparent or pale yellow structure. The liquid is contained in ampoules of 1 ml each. Ampoules are placed in cardboard packaging of 5 or 10 pieces

Components

The composition of the drug Ketanov includes the following components:

Active substance – ketorolac tromethamine

Additional components of the tablets:

• Colloidal silicon dioxide
• Magnesium stearate
• Corn starch
• Microcrystalline cellulose

Components of the film shell:

• Macrogol 400
• Titanium dioxide
• Hydroxypropyl methylcellulose
• Purified talc
• Purified water

Additional components of the solution:

• Disodium edetate
• Sodium hydroxide
• Ethanol
• Sodium chloride
• Water for injections

Composition and release form

Taking Ketanov for toothache allows you to get results that are difficult to achieve with conventional non-steroidal anti-inflammatory drugs. The drug does not cause sedation and inhibition of reactions. According to the instructions for use, Ketanov is allowed to be taken during the working day without compromising productivity.

The Indian company Ranbaxy produces the drug in the form of tablets or solution for injection. The latter is used for the treatment of toothache only in extreme cases and as prescribed by a doctor.

The pronounced analgesic effect of the drug is due to the main active substance – ketorolac . The active substance suppresses the production of prostaglandins in the body. They are responsible for the development of pain and inflammation. Reducing the amount of prostaglandins allows for complete pain relief without a specific effect on individual nerves.

Taking Ketanov has a systemic effect on the entire body. Treatment of toothache with this drug allows you to simultaneously relieve pain of any location.

Among the auxiliary components of the drug are:

• silica;
• starch;
• Magnesium stearate.

All of them do not have medicinal properties and are used only as a supplement to the main active ingredient, correcting its work.

The benefits of the drug Ketanov

Still, before taking an analgesic drug, it is worth finding out what effect it has on the body.

In addition to pain relief, Ketanol has antipyretic and anti-inflammatory effects.

According to the characteristics in the instructions for use, the drug can have antipyretic, anti-inflammatory and analgesic effects. Therefore, many patients use this medicine not only for toothache, but also to alleviate the condition of various disorders and disorders of other organs. In addition, the drug Ketanov is able to eliminate the discomfort that occurs with diseases such as pulpitis and periodontitis.

After using the drugs, people do not feel drowsiness, fatigue, or lethargy. If after use there is no physical pressure on the affected area, the pain will go away after some time. Usually the pain completely disappears after 1-2 hours.

Advantages

The positive qualities include the following features of the drug Ketanov:

• This drug can eliminate painful sensations that are of high intensity
• Helps even in situations where other analgesics are powerless
• Compared to other painkillers, it has minimal side effects
• Long-lasting analgesic effect from 6 to 8 hours
• Subject to abrupt cancellation
• Non-addictive, even with prolonged use for 6 months

What are the advantages of the drug

The main advantages of Ketanov are its following features:

• the ability to relieve severe pain of various origins, when other medications are helpless;
• minimum “side effects” when taken (compared to other painkillers);
• long-term analgesic effect (at least 6-8 hours);
• the possibility of abrupt drug withdrawal and the absence of addiction syndrome (withdrawal) even after a long course of administration (up to 6 months).

By-effect

Unfortunately, in some people this drug can cause a lot of unpleasant phenomena in the body. The most common of them include:

• dyspeptic symptoms (dry mouth, nausea or vomiting, inflammation of the stomach or exacerbation of ulcers, constipation or diarrhea, stomach pain);
• neurological changes (headache or dizziness, nervousness or excessive drowsiness, hyperesthesia of some parts of the body);
• from the ENT organs (sometimes it reduces hearing or provokes ringing in the ears, and can impair vision);
• therapeutic disorders (high blood pressure, slow heartbeat);
• from the urinary organs - swelling is sometimes possible.

How to properly use Ketanov for toothache

The drug Ketanov is one of the best remedies that are used during toothache. This remedy helps reduce not only pain, but also eliminates the inflammatory process.

The period of action of the medicine is 4-8 hours. Usually this time is enough for the patient to seek help from a specialist.

Features of application:

• Tablets should be taken orally
• To make it easier to take, take it with liquid.
• Maximum 5 tablets per day
• Can be taken in the morning, at lunch, in the evening, before bedtime
• The main thing is that at least 4 hours should pass between doses.
• Should be taken on an empty stomach
• Half an hour after use you can eat food
• The maximum course of use should be no more than 7 days

Specifics of Ketanov treatment for toothache

Relief from acute toothache occurs within 30 minutes after taking Ketanov . The analgesic effect lasts for 7 hours. At the first signs of return of pain, repeated administration of the drug is allowed. The maximum dosage is limited to 4 tablets per day.

Severe toothache is often accompanied by inflammatory processes. If it is not possible to immediately consult a dentist, it is recommended to relieve pain with Ketanov. In addition to the analgesic effect, it helps prevent the progression of the inflammatory process and relieve fever.

Blocking the enzymes responsible for the formation of pain does not allow Ketanov to fight muscle spasms. In the line of analogues, Ketanov stands out for its ability to quickly act on the source of unpleasant sensations, the strength of the effect and the rapid removal of tissue swelling.

When to take Ketanov for toothache

Dentists often prescribe Ketanol after tooth extraction

Ketanov is often prescribed after tooth extraction. In these situations, pain decreases almost instantly. Usually after 1 hour the pain goes away completely.

Ketanov is also prescribed for the following conditions:

• In case of inflammation of the root or nerve (pulpitis)
• During a carious tooth lesion
• Dentitis
• Recommended for use in case of flux or internal suppuration
• For periodontal disease

Contraindications

Despite the fact that the analgesic drug Ketanov has good properties, it has a lot of contraindications.

Use of this medicine is not recommended for the following conditions:

• In the presence of individual intolerance;
• If you have bronchial or aspirin-induced asthma, bronchospasms;
• Kidney, heart, liver failure;
• Disorder of the functioning of the hematopoietic system;
• Bone marrow disorders;
• If serious problems arise in the activity of the gastrointestinal tract - exacerbation of gastric ulcers, cirrhosis of the liver, hepatitis;
• In the postoperative period, there is a high risk of bleeding;
• If you have polyps in the nose or paranasal sinuses;
• In the post-stroke period.

Use with caution in the following conditions:

• If there are bleeding disorders, it is necessary to monitor the level of platelets in the blood
• Use with caution during diabetes mellitus, hypertension, lupus erythematosus, sepsis
• It should be taken with caution by people whose professional activities require increased attention. also used with caution when driving vehicles
• Not recommended for use by elderly people over 65 years of age

Features of use for children, pregnant women and during breastfeeding

Ketanol is contraindicated during pregnancy, breastfeeding, and children under 16 years of age.

The drug Ketanov is not recommended for use by pregnant women. The constituent components have a harmful effect on the child. Also, you should not use the medicine during childbirth.

Since the constituent components are excreted in breast milk, the drug is not used during breastfeeding.

Important! Contraindicated for use in children. Ketanov can only be used by adults and adolescents over 16 years of age. Sometimes in exceptional cases it is used for children from 2 years of age.

Ketanov 10 mg 100 pcs. film-coated tablets

pharmachologic effect

NSAID, derivative of pyrrolysine-carboxylic acid. It has a pronounced analgesic effect, and also has anti-inflammatory and moderate antipyretic effects. The mechanism of action is associated with inhibition of the activity of COX, the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.

Composition and release form Ketanov 10 mg 100 pcs. film-coated tablets

Tablets - 1 tablet: ketorolac tromethamine 10 mg.

10 pieces. — contour cell packaging (10) — cardboard packs.

Description of the dosage form

Film-coated tablets.

Directions for use and doses

For adults, when taken orally - 10 mg every 4-6 hours, if necessary - 20 mg 3-4 times a day.

For intramuscular administration, a single dose is 10-30 mg, the interval between injections is 4-6 hours. The maximum duration of use is 2 days.

Maximum doses: when taken orally or intramuscularly - 90 mg/day; for patients weighing up to 50 kg, with impaired renal function, as well as for persons over 65 years of age - 60 mg/day.

Pharmacodynamics

The analgesic effect occurs after approximately 30 minutes, the maximum analgesic effect develops after 1-2 hours. The duration of the analgesic effect is 4-6 hours or more, depending on the dose. Does not have a sedative or anxiolytic effect, does not affect opioid receptors. It does not have a depressant effect on the respiratory center and does not enhance respiratory depression and sedation caused by opioid analgesics. Does not cause drug dependence. No withdrawal symptoms occur after abrupt cessation of use. Suppresses platelet aggregation and may cause prolongation of bleeding time. Restoration of platelet function occurs 24-48 hours after discontinuation of the drug.

Pharmacokinetics

When taken orally, it is absorbed from the gastrointestinal tract. Cmax in blood plasma is achieved 40-50 minutes after both oral and intramuscular administration. Eating does not affect absorption. Plasma protein binding is more than 99%.

T1/2 - 4-6 hours both after oral administration and after intramuscular administration.

More than 90% of the dose is excreted in the urine, unchanged - 60%; the remaining amount is through the intestines.

In patients with impaired renal function and the elderly, the elimination rate decreases, T1/2 increases.

Indications for use Ketanov 10 mg 100 pcs. film-coated tablets

For short-term relief of moderate and severe pain of various origins.

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, the presence or suspicion of gastrointestinal bleeding and/or cerebral hemorrhage, a history of blood coagulation disorders, conditions with a high risk of bleeding or incomplete hemostasis, hemorrhagic diathesis, moderate and severe renal dysfunction ( serum creatinine content more than 50 mg/l), the risk of developing renal failure due to hypovolemia and dehydration; “aspirin triad”, bronchial asthma, nasal polyps, history of angioedema, preventive pain relief before and during surgery, childhood and adolescence up to 16 years of age, pregnancy, childbirth, lactation, hypersensitivity to ketorolac, acetylsalicylic acid and other NSAIDs .

Application of Ketanov 10 mg 100 pcs. film-coated tablets during pregnancy and breastfeeding

Contraindicated during pregnancy, during childbirth and during lactation (breastfeeding).

Ketorolac is contraindicated for use as a premedication, maintenance of anesthesia and for pain relief in obstetric practice, since its influence may increase the duration of the first stage of labor. In addition, ketorolac may inhibit uterine contractility and fetal circulation.

Use with caution in patients with impaired renal function.

Use in children

Contraindicated in children and adolescents under 16 years of age.

special instructions

Use with caution in patients with impaired liver and kidney function, chronic heart failure, arterial hypertension, in patients with erosive and ulcerative lesions of the gastrointestinal tract and a history of bleeding from the gastrointestinal tract.

Ketorolac should be used with caution in the postoperative period in cases where particularly careful hemostasis is required (including after resection of the prostate gland, tonsillectomy, in cosmetic surgery), as well as in elderly patients, because The half-life of ketorolac is prolonged and plasma clearance may be reduced. In this category of patients, it is recommended to use ketorolac in doses close to the lower limit of the therapeutic range. If symptoms of liver damage, skin rash, or eosinophilia appear, ketorolac should be discontinued. Ketorolac is not indicated for use in chronic pain syndrome.

Impact on the ability to drive vehicles and operate machinery

If drowsiness, dizziness, insomnia or depression appear during treatment with ketorolac, special care must be taken when engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Overdose

Symptoms: (with a single dose) abdominal pain, nausea, vomiting, peptic ulcers, impaired renal function (these symptoms disappeared after discontinuation of the drug). Treatment: symptomatic therapy. Dialysis does not significantly remove ketorolac from the blood.

Side effects of Ketanov 10 mg 100 pcs. film-coated tablets

From the cardiovascular system: rarely - bradycardia, changes in blood pressure, palpitations, fainting.

From the digestive system: possible nausea, abdominal pain, diarrhea; rarely - constipation, flatulence, feeling of gastrointestinal fullness, vomiting, dry mouth, thirst, stomatitis, gastritis, erosive and ulcerative lesions of the gastrointestinal tract, liver dysfunction.

From the central nervous system and peripheral nervous system: anxiety, headache, drowsiness are possible; rarely - paresthesia, depression, euphoria, sleep disturbances, dizziness, changes in taste, visual disturbances, motor disorders.

From the respiratory system: rarely - respiratory failure, attacks of suffocation.

From the urinary system: rarely - increased frequency of urination, oliguria, polyuria, proteinuria, hematuria, azotemia, acute renal failure.

From the blood coagulation system: rarely - nosebleeds, anemia, eosinophilia, thrombocytopenia, bleeding from postoperative wounds.

Metabolism: possible increased sweating, swelling; rarely - oliguria, increased levels of creatinine and/or urea in the blood plasma, hypokalemia, hyponatremia.

Allergic reactions: possible skin itching, hemorrhagic rash; in isolated cases - exfoliative dermatitis, urticaria, Lyell's syndrome, Stevens-Johnson syndrome, anaphylactic shock, bronchospasm, Quincke's edema, myalgia.

Other: possible fever.

Local reactions: pain at the injection site.

Drug interactions

When ketorolac is used concomitantly with other NSAIDs, additive side effects may develop; with pentoxifylline, anticoagulants (including heparin in low doses) - the risk of bleeding may increase; with ACE inhibitors - there may be an increased risk of developing renal dysfunction; with probenecid - the plasma concentration of ketorolac and its half-life increase; with lithium preparations - a decrease in the renal clearance of lithium and an increase in its concentration in plasma is possible; with furosemide - reducing its diuretic effect.

When using ketorolac, the need for the use of opioid analgesics for pain relief is reduced.

Side effects

During use, this product can cause various unpleasant phenomena. The most common side effects include the following:

• Dyspeptic symptoms may appear - nausea, vomiting, stool upset, dry mouth, pain in the abdomen, exacerbation of gastric ulcers
• Headaches, dizziness
• Increased sleepiness
• Phenomena of nervousness
• Hearing loss
• The occurrence of ringing in the ears
• Vision problems
• Increased blood pressure
• Slow heartbeat
• Edema

In any case, you should take this analgesic only when absolutely necessary.

Taking medication will only help temporarily. Only a dentist can relieve you of toothache

It is advisable to use it as an emergency aid for severe pain in the tooth. But after use, you should immediately consult a doctor. The dentist will examine the tooth and provide the necessary treatment.

Recommendations for use

The drug is taken orally as needed, without making adjustments to food intake. It is permissible to take no more than 1 tablet at a time. At least 6 hours should pass between doses. It is recommended to limit the treatment course to 5 days. If the pain does not subside, you should immediately consult a dentist to eliminate the cause of the symptom.

Treatment of toothache with Ketanov requires the patient to observe a rest regime for the affected tooth. It is necessary to minimize the pressure on it when biting and chewing. Otherwise, even such a potent drug will not be able to completely relieve the discomfort.

One Ketanov tablet is designed for single use by a person whose body weight is 60 + 5 kg. If the patient’s weight is significantly greater, then the single dosage may be doubled. The drug can be used without adjustments to food intake, but use after meals helps to significantly reduce the risk of side effects. Experts recommend taking the tablets with milk or still mineral water.

Ketanov injections for toothache are given only on the recommendation of a doctor. The effect of the drug appears within 30 minutes and lasts up to 12 hours. If the discomfort returns earlier, then giving a second injection or taking a pill before 12 hours has passed is prohibited.